Separation of N-alkyl phenothiazine sulfones by HPTLC using an optimum mobile phase.
نویسندگان
چکیده
In high performance thin layer chromatography some form of optimization is necessary if complete separation of all components is required. The selection of mobile phase composition is one of the most important components of an optimization strategies. The aim of this paper is the separation of the N-alkyl phenothiazine sulfones by high performance thin layer chromatography using an optimum mobile phase system. The optimum composition of mobile phase (toluene-ethyl ether-chloroform, 30:50:20, v/v) are given by the maximum of objective function (F(obj)=10.6110).
منابع مشابه
Influence of the Anionic Part of 1-Alkyl-3-Methylimidazolium-Based Ionic Liquids on the Chromatographic Behavior of Perazine in RP-HPTLC
1-Alkyl-3-methylimidazolium-based ionic liquids (tetrafluoroborate, L-(þ)-lactate and ethyl sulfate) were used as mobile phase additives to assess the effect of its anionic part on the retention mechanism of perazine in pharmaceutical formulation in reversed-phase highperformance thin-layer chromatography (RP-HPTLC) method. In all cases, significant changes and improvements in the retention fac...
متن کاملSEPARATION OF POLYCYCLIC AROMATIC HYDROCARBONS WITH MIXED MICELLAR HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Separation of Polycyclic Aromatic Hydrocarbons was performed by RP-HPLC using mixed micellar mobile phase. Effect of temperature, types and amounts of coorganic solvent in mobile phase on efficiency, asymmetry factor and selectivity factor showed that the appropriate condition for separation of these compounds was 3% isopropanol (V/V) as co-organic solvent in mobile phase at 40°C. Analysis of...
متن کاملSeparation of Sedative – Hypnotic Drugs with Mixed Micellar Liquid Chromatography
Separation of ten sedative- hypnotic drugs was performed by RP-HPLC using mixed micellar mobile phase. Effect of temperature, type and amount of organic modifier in mobile phase on efficiency (N) and asymmetry factor (B/A) showed that, the appropriate conditions for a good separation were 35°C and 7% (V/V) butanol in mobile phase. Variations of selectivity factor versus butanol concent...
متن کاملSeparation of Vitamin B2 and B12 byImpregnate HPTLC Plates with Boric Acid
A high performance thin layer chromatography system (HPTLC) for the separation of vitamin B2 and B12 has been developed. The separation was successfully using a solvent system of methanol, water, ammonia 7.3.1 (V/V) as mobile phase on HPTLC plates impregnated with boric acid. The effect of other mobile phases on the separation of vitamins was also examined. The method is based on different beha...
متن کاملHPTLC-Densitometric Determination of Cetirizine and Montelukast Analysis in Combined Tablet Dosage Forms
A simple, accurate and rapid high performance thin layer chromatography (HPTLC)-densitometric method was developed for separation and determination of cetirizine (CET) as a long acting antihistamine and montelukast (MON) as an antileukotriene in pharmaceutical dosage forms. The compounds were separated on silica gel 60 F254 HPTLC plates using a mixture of ethyl acetate : methanol : ammonia solu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of pharmaceutical and biomedical analysis
دوره 28 2 شماره
صفحات -
تاریخ انتشار 2002